Cortical anatomy in human X monosomy

Sex differences in cortical and subcortical human brain anatomy

Previous research has reported many sex differences in cortical and subcortical anatomy, but only a subset of findings is consistent across studies. Here, we used improved Freesurfer-based automated methods to analyze the properties of the cortex and seven subcortical structures in young, right-handed subjects (69 male and 69 female), carefully matched in age and education. Significant sex diff...

Function-based Intersubject Alignment of Human Cortical Anatomy

Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on funct...

Inter-subject alignment of human cortical anatomy using functional connectivity

Inter-subject alignment of functional MRI (fMRI) data is necessary for group analyses. The standard approach to this problem matches anatomical features of the brain, such as major anatomical landmarks or cortical curvature. Precise alignment of functional cortical topographies, however, cannot be derived using only anatomical features. We propose a new inter-subject registration algorithm that...

Mechanism for Autoimmune Diseases X Chromosome Monosomy: A Common

The Biochemical Anatomy of Cortical Inhibitory Synapses

Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have established the paradigm of the synapse as a complex signal-processing machine that controls synaptic plasticity. We report here the results of a p...